Article
BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.
Blood cells, molecules & diseases - 1 Jan 2000
Sedgewick Amanda E, Timofeev Nadia, Sebastiani Paola, So Jason C C, Ma Edmond S K, Chan Li Chong, Fucharoen Goonnapa, Fucharoen Supan, Barbosa Cynara G, Vardarajan Badri N, Farrer Lindsay A, Baldwin Clinton T, Steinberg Martin H, Chui David H K
Abstract excerpt
Increased HbF levels or F-cell (HbF containing erythrocyte) numbers can ameliorate the disease severity of beta-thalassemia major and sickle cell anemia. Recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in BCL11A gene on chromosome 2p16.1 were correlated with F-cells among healthy northern Europeans, and HbF among Sardinians with beta-thalassemias. In this study, we...
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