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Article

Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin

18 Jul 2007

Abstract excerpt

Butyrate is a prototype of histone deacetylase inhibitors that is believed to reactivate silent genes by inducing epigenetic modifications. Although butyrate was shown to induce fetal hemoglobin (HbF) production in patients with hemoglobin disorders, the mechanism of this induction has not been fully elucidated. Our studies of the epigenetic configuration of the beta-globin cluster suggest that DNA methylation...

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Share to Epigenetics and DNA Methylation
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PMID: 17638855
DOI: 10.1182/blood-2007-02-076091

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