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Article

Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis.

BMC bioinformatics - 19 Jan 2009

Frech Christian, Kommenda Michael, Dorfer Viktoria, Kern Thomas, Hintner Helmut, Bauer Johann W, Onder Kamil

Abstract excerpt

BACKGROUND: Protein-protein interaction (PPI) data sets generated by high-throughput experiments are contaminated by large numbers of erroneous PPIs. Therefore, computational methods for PPI validation are necessary to improve the quality of such data sets. Against the background of the theory that most extant PPIs arose as a consequence of gene duplication, the sensitive search for homologous PPIs, i.e. for PPIs...

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Source

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Identifiers

PMID: 19152684
DOI: 10.1186/1471-2105-10-21
PMCID: PMC2637843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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