Article
Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia.
Blood - 15 Jan 1999
Hunter M G, Avalos B R
Abstract excerpt
Acquired mutations in the granulocyte colony-stimulating factor receptor (G-CSFR) occur in a subset of patients with severe congenital neutropenia (SCN) who develop acute myelogenous leukemia (AML). These mutations affect one allele and result in hyperproliferative responses to G-CSF, presumably...
Topics
- Amino Acid Sequence
- Animals
- Binding, Competitive
- COS Cells
- Cell Division
- Electrophoresis, Polyacrylamide Gel
- Gene Deletion
- Granulocyte Colony-Stimulating Factor
- Humans
- Immunosorbent Techniques
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Neutropenia
- Phenotype
- Receptors, Granulocyte Colony-Stimulating Factor
- Transfection