Article
Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration.
Molecular cell - 16 Jan 2009
Henao-Mejia Jorge, Liu Ying, Park In-Woo, Zhang Jizhong, Sanford Jeremy, He Johnny J
Abstract excerpt
HIV-1 Nef plays important roles in HIV-1 replication and pathogenesis. It is translated from completely spliced HIV-1 RNA, and its expression is inherently regulated at the levels of viral DNA transcription and RNA splicing. Here we show that Sam68 cytoplasmic mutants potently suppress Nef expression. The suppression requires Sam68 domain aa 269-321 and is correlated with its ability to induce stress granules. In...
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