Article
Analysis of gene polymorphisms in the regulatory region of MCP-1, RANTES, and CCR5 in liver transplant recipients.
Journal of clinical immunology - 1 Nov 2002
Schröppel Bernd, Fischereder Michael, Lin Marvin, Marder Brad, Schiano Tom, Krämer Bernhard K, Murphy Barbara
Abstract excerpt
Chemokines and their receptors play a major role in the inflammatory and immune responses that mediate allograft outcome. The production of some chemokines varies among individuals and these variations may be determined by genetic polymorphisms, most commonly within the regulatory region of the gene. We investigated whether the functional polymorphisms of the chemokines RANTES, MCP-1 and chemokine receptor CCR5...
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