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Article

KSR1 is required for cell cycle reinitiation following DNA damage.

The Journal of biological chemistry - 13 Mar 2009

Razidlo Gina L, Johnson Heidi J, Stoeger Scott M, Cowan Kenneth H, Bessho Tadayoshi, Lewis Robert E

Abstract excerpt

KSR1 (kinase suppressor of Ras 1) is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. We show here that KSR1 is also required for maximal ERK activation induc...

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Source

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Identifiers

PMID: 19147494
DOI: 10.1074/jbc.M806457200
PMCID: PMC2652329

Genes

KSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19147494-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

KSR1 is required for cell cycle reinitiation following DNA damage.PMID 19147494Read ↗

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.Semantic proximity Read ↗

Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.Semantic proximity Read ↗

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.Semantic proximity Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.Semantic proximity Read ↗

Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.Semantic proximity Read ↗

Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells.Semantic proximity Read ↗

Requirement for p53 and p21 to sustain G2 arrest after DNA damage.Semantic proximity Read ↗

The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.Semantic proximity Read ↗

Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays.Semantic proximity Read ↗

Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras.Semantic proximity Read ↗

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