Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Tian Hui, Faje Alexander T, Lee Siu Lan, Jorgensen Timothy J

Abstract excerpt

Because DNA damage-inducible cell cycle checkpoints are thought to protect cells from the lethal effects of ionizing radiation, a better understanding of the mechanistic functions of cell cycle regulatory proteins may reveal new molecular targets for cancer therapy. The two major regulatory proteins of G2 arrest are Chk1 and p53. Yet, it is unclear how these two proteins interact and coordinate their functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Alkaloids
Share to Checkpoint Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colony-Forming Units Assay

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclins

Share to Staurosporine

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 11896572
DOI: 10.1038/sj.neo.7900219
PMCID: PMC1550321

Genes

UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.PMID 11896572Read ↗

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Semantic proximity Read ↗

p53‐dependent G1 arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitorsSemantic proximity Read ↗

Chk1 Inhibitors for Novel Cancer TreatmentSemantic proximity Read ↗

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.Semantic proximity Read ↗

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.Semantic proximity Read ↗

Molecular Basis for G2 Arrest Induced by 2′- C -Cyano-2′-Deoxy-1-β- d - Arabino -Pentofuranosylcytosine and Consequences of Checkpoint AbrogationSemantic proximity Read ↗

Targeting Checkpoint Kinase 1 in Cancer TherapeuticsSemantic proximity Read ↗

Cell cycle checkpoints and repair of ionizing radiation damage.Semantic proximity Read ↗

Cell cycle checkpoints, genetic instability and cancer.Semantic proximity Read ↗

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.Semantic proximity Read ↗

Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress.Semantic proximity Read ↗

Molecular mechanisms regulating the G2 checkpoint induced after DNA damageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.