Article
Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations.
PloS one - 1 Jan 2009
Mangano Valentina D, Clark Taane G, Auburn Sarah, Campino Susana, Diakite Mahamadou, Fry Andrew E, Green Angela, Richardson Anna, Jallow Muminatou, Sisay-Joof Fatou, Pinder Margaret, Griffiths Michael J, Newton Charles, Peshu Norbert, Williams Thomas N, Marsh Kevin, Molyneux Malcolm E, Taylor Terrie E, Modiano David, Kwiatkowski Dominic P, Rockett Kirk A
Abstract excerpt
Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type responses. It is therefore likely to be crucial in both innate and adaptive responses against intracellular pathogens...
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