Article
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
Nature communications - 28 Nov 2017
Liu Juan, Zhang Cen, Zhao Yuhan, Yue Xuetian, Wu Hao, Huang Shan, Chen James, Tomsky Kyle, Xie Haiyang, Khella Christen A, Gatza Michael L, Xia Dajing, Gao Jimin, White Eileen, Haffty Bruce G, Hu Wenwei, Feng Zhaohui
Abstract excerpt
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1α (HIF-1α). Parkin interacts with HIF-1α and promotes HIF-1α degradation through ubiquitination, which in turn inhibits...
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