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The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

27 Mar 2024

Abstract excerpt

Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic and inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), and cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts metabolic and immune signaling leading to metabolic endotoxemia, while short-chain fatty acids (SCFAs)...

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PMID: 38605957
DOI: 10.3389/fimmu.2024.1380476

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