Article
Syntaxin 7 mediates endocytic trafficking to late endosomes.
The Journal of biological chemistry - 3 Mar 2000
Nakamura N, Yamamoto A, Wada Y, Futai M
Abstract excerpt
The lysosome functions are ensured by accurate membrane trafficking in the cell. We found that mouse syntaxin 7 could complement yeast vam3 and pep12 mutants defective in docking/fusion to vacuolar and prevacuolar membranes, respectively. Immunohistochemical studies showed that syntaxin 7 is localized to late endosomes, but not to early endosomes. Induced expression of mutant syntaxin 7 blocked endocytic...
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