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Article

MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth.

Diabetes, obesity & metabolism - 1 Feb 2009

Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez E R, Walter M, Rosinger S, Ziegler A, Böhm B O

Abstract excerpt

AIM: The region on chromosome 6p21 (IDDM1) confers the largest part of genetic susceptibility to type 1 diabetes (T1D) with particular human leucocyte antigen (HLA) alleles predisposing and others protecting from it. As T1D is primarily a "sporadic" disease, the pathophysiology must involve gene-environment interactions. We searched for indirect evidence for such major histocompatibility complex (MHC)-environment...

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Source

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Identifiers

PMID: 19143820
DOI: 10.1111/j.1463-1326.2008.01008.x
PMCID: PMC2759302

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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