Article
Environmental triggers of type 1 diabetes.
Journal of paediatrics and child health - 1 Jun 2001
Couper J J
Abstract excerpt
High risk HLA class II alleles account for 40% of the genetic susceptibility to type 1 diabetes in Caucasians, but the majority of the genetically predisposed do not develop the disease. This supports some environmental modification of the autoimmune destruction of beta cells that precedes type 1 diabetes. Identical twin studies and geographical variation in incidence also argue for a critical role of...
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