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Article

Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner.

PloS one - 1 Jan 2009

Oyama Satoko, Yamakawa Hidekuni, Sasagawa Noboru, Hosoi Yoshio, Futai Eugene, Ishiura Shoichi

Abstract excerpt

DTNBP1 has been recognized as a schizophrenia susceptible gene, and its protein product, dysbindin-1, is down-regulated in the brains of schizophrenic patients. However, little is known about the physiological role of dysbindin-1 in the central nervous system. We hypothesized that disruption of dysbindin-1 with unidentified proteins could contribute to pathogenesis and the symptoms of schizophrenia. GST pull-down...

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Source

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Identifiers

PMID: 19142223
DOI: 10.1371/journal.pone.0004199
PMCID: PMC2614472

Genes

DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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