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Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

24 Mar 2017

Abstract excerpt

The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susceptibility in human. Although Foxa2 has been shown to directly regulate Pdx1 expression during mouse embryonic development, the...

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PMID: 28580283
DOI: 10.1016/j.molmet.2017.03.007

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