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Article

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.

Developmental biology - 1 Apr 2008

Burlison Jared S, Long Qiaoming, Fujitani Yoshio, Wright Christopher V E, Magnuson Mark A

Abstract excerpt

The pancreas is derived from a pool of multipotent progenitor cells (MPCs) that co-express Pdx-1 and Ptf1a. To more precisely define how the individual and combined loss of Pdx-1 and Ptf1a affects pancreatic MPC specification and differentiation we derived and studied mice bearing a novel Ptf1a(YFP) allele. While the expression of Pdx-1 and Ptf1a in pancreatic MPCs coincides between E9.5 and 12.5 the...

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Identifiers

PMID: 18294628
DOI: 10.1016/j.ydbio.2008.01.011
PMCID: PMC2425677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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