Abnormalities of prothrombin: a review of the pathophysiology, diagnosis, and treatment.

Abstract excerpt

Prothrombin (factor II) deficiency is a rare autosomal recessive coagulation disorder that occurs in approximately 1 in 1-2 million people. Prothrombin is activated to thrombin, which in turn proteolytically cleaves fibrinogen to fibrin and contributes to forming a stable fibrin clot. The haemostatic level of prothrombin is thought to be between 20 and 40%, and the half-life is approximately 3 days. There are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Coagulation
• Share to Blood Coagulation Factors
• Share to Blood Coagulation Tests