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Article

Congenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.

Hematology (Amsterdam, Netherlands) - 1 Mar 2018

Girolami Antonio, Ferrari Silvia, Cosi Elisabetta, Girolami Bruno, Lombardi Anna Maria

Abstract excerpt

OBJECTIVE: Congenital prothrombin deficiency is one of the rarest clotting disorders. It is commonly subdivided in Type I defects or cases of 'true' prothrombin deficiency characterized by a concomitant decrease in FII activity and antigen and in Type II or dysprothrombinemias, in which FII activity is low but FII antigen is normal or near normal. A bleeding tendency, often a severe one, is the hallmark of the...

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PMID: 28762299
DOI: 10.1080/10245332.2017.1359900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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