Article
Factor V deficiency: a concise review.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Nov 2008
Huang J N, Koerper M A
Abstract excerpt
Factor V (FV; proaccelerin or labile factor) is the plasma cofactor for the prothrombinase complex that activates prothrombin to thrombin. FV deficiency can be caused by mutations in the FV gene or in genes encoding components of a putative cargo receptor that transports FV (and factor VIII) from the endoplasmic reticulum to the Golgi. Because FV is present in platelet alpha-granules as well as in plasma, low FV...
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