Article
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Journal of neurochemistry - 1 Feb 2009
Yasuda Toru, Nihira Tomoko, Ren Yong-Ri, Cao Xu-Qing, Wada Keiichiro, Setsuie Rieko, Kabuta Tomohiro, Wada Keiji, Hattori Nobutaka, Mizuno Yoshikuni, Mochizuki Hideki
Abstract excerpt
The rare inherited form of Parkinson's disease (PD), PARK5, is caused by a missense mutation in ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) gene, resulting in Ile93Met substitution in its gene product (UCH-L1(Ile93Met)). PARK5 is inherited in an autosomal-dominant mode, but whether the Ile93Met mutation gives rise to a gain-of-toxic-function or loss-of-function of UCH-L1 protein remains controversial. Here,...
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