Article
[The ubiquitin-proteasome system and neurodegeneration].
Rinsho shinkeigaku = Clinical neurology - 1 Dec 2001
Wada K, Osaka H, Aoki S, Wang Y L
Abstract excerpt
Many studies have suggested the ubiquitin-proteasome system played an essential role in the pathogenesis of neurodegenerative disorders. In 1999, we provided evidence that a mutation of the system could directly cause neurodegeneration using the gad mouse. Namely, we identified the gad mutation was caused by an intragenic deletion of a gene encoding ubiquitin C-terminal hydrolase 1(UCH-L1), which is a member of...
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