Article
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.
Neurochemistry international - 1 Jan 2007
Setsuie Rieko, Wang Yu-Lai, Mochizuki Hideki, Osaka Hitoshi, Hayakawa Hideki, Ichihara Nobutsune, Li Hang, Furuta Akiko, Sano Yae, Sun Ying-Jie, Kwon Jungkee, Kabuta Tomohiro, Yoshimi Kenji, Aoki Shunsuke, Mizuno Yoshikuni, Noda Mami, Wada Keiji
Abstract excerpt
The I93M mutation in ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) was reported in one German family with autosomal dominant Parkinson's disease (PD). The causative role of the mutation has, however, been questioned. We generated transgenic (Tg) mice carrying human UCHL1 under control of the PDGF-B promoter; two independent lines were generated with the I93M mutation (a high- and low-expressing line) and one...
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