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Article

Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.

PloS one - 1 Jan 2012

Cartier Anna E, Ubhi Kiren, Spencer Brian, Vazquez-Roque Ruben A, Kosberg Kori Ann, Fourgeaud Lawrence, Kanayson Priya, Patrick Christina, Rockenstein Edward, Patrick Gentry N, Masliah Eliezer

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Abnormal accumulation and aggregation of alpha-synuclein (a-syn) within neurons, and mutations in the a-syn and UCH-L1 genes have been shown to play a role in the pathogenesis of PD. In light of recent reports suggesting an interaction between a-synuclein and UCH-L1, we investigated the effects of...

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Identifiers

PMID: 22514658
DOI: 10.1371/journal.pone.0034713
PMCID: PMC3326048

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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