Article

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson’s Disease and Neurodegenerative Disorders

2016-12-17

Abstract excerpt

Parkinson’s disease (PD) is one of the most common progressive neurodegenerative disorders in modern society. The disease involves many genetic risk factors as well as a sporadic pathogenesis that is age- and environment-dependent. Of particular interest is the formation of intra-neural fibrillar aggregates, namely Lewy bodies (LBs), the histological hallmark of PD, which results from aberrant protein homeostasis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4e35cac-1325-5573-92f4-db55ca000978
DOI: 10.1101/094953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson’s Disease and Neurodegenerative DisordersDOI 10.1101/094953Read

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.Semantic proximity Read

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1Semantic proximity Read

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.Semantic proximity Read

The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.Semantic proximity Read

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Semantic proximity Read

Insights into links between familial and sporadic Parkinson's disease: Physical relationship between UCH-L1 variants and chaperone-mediated autophagySemantic proximity Read

The functions of UCH-L1 and its relation to neurodegenerative diseases.Semantic proximity Read

Novel UCHL1 mutations reveal new insights into ubiquitin processing.Semantic proximity Read

The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.Semantic proximity Read

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body DisordersSemantic proximity Read

Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in NeurodegenerationSemantic proximity Read

The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1.Semantic proximity Read