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Article

The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity.

The International journal of developmental biology - 1 Jan 2017

Koltun Bella, Shackelford Eliza, Bonnay François, Matt Nicolas, Reichhart Jean Marc, Orian Amir

Abstract excerpt

The ability of metazoans to combat pathogenic infection involves both systemic and local responses to the invading pathogens. Ubiquitin and SUMO pathways molecularly regulate the response to infection, immune signaling and gene expression. Here, we report that Degringolade (Dgrn, CG10981), a SUMO-targeted ubiquitin ligase connecting the two pathways, is essential for the innate immunity response in Drosophila....

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Source

Identifiers

PMID: 28621429
DOI: 10.1387/ijdb.160250ao

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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