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Article

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.

Molecular and cellular biology - 1 Aug 1997

Jiménez G, Ish-Horowicz D

Abstract excerpt

Drosophila melanogaster neurogenesis requires the opposing activities of two sets of basic helix-loop-helix (bHLH) proteins: proneural proteins, which confer on cells the ability to become neural precursors, and the Enhancer-of-split [E(spl)] proteins, which restrict such potential as part of the lateral inhibition process. Here, we test if E(spl) proteins function as promoter-bound repressors by examining the...

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Identifiers

PMID: 9234693
DOI: 10.1128/MCB.17.8.4355
PMCID: PMC232289

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A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.PMID 9234693Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.Semantic proximity Read ↗

Two modes of recruitment of E(spl) repressors onto target genes.Semantic proximity Read ↗

The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.Semantic proximity Read ↗

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila.Semantic proximity Read ↗

Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.Semantic proximity Read ↗

Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster.Semantic proximity Read ↗

Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function.Semantic proximity Read ↗

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.Semantic proximity Read ↗

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.Semantic proximity Read ↗

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.Semantic proximity Read ↗

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