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Article

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain.

The Journal of cell biology - 1 Jul 1992

Metsäranta M, Garofalo S, Decker G, Rintala M, de Crombrugghe B, Vuorio E

Abstract excerpt

We have generated transgenic mice by microinjection of a 39-kb mouse pro alpha 1(II) collagen gene construct containing a deletion of exon 7 and intron 7. This mutation was expected to disturb the assembly and processing of the homotrimeric type II collagen molecule in cartilage. Expression of transgene mRNA at levels equivalent or higher than the endogenous mRNA in the offspring of two founder animals resulted...

Topics

Animals
Bone and Bones
Cartilage
Collagen
Exons
Extracellular Matrix
Mice
Mice, Transgenic
Morphogenesis
Mutagenesis
Osteogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Conformation

RNA, Messenger

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Identifiers

PMID: 1618904
DOI: 10.1083/jcb.118.1.203
PMCID: PMC2289514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1618904-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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