Article
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.
Blood - 29 May 2014
Rampal Raajit, Al-Shahrour Fatima, Abdel-Wahab Omar, Patel Jay P, Brunel Jean-Philippe, Mermel Craig H, Bass Adam J, Pretz Jennifer, Ahn Jihae, Hricik Todd, Kilpivaara Outi, Wadleigh Martha, Busque Lambert, Gilliland D Gary, Golub Todd R, Ebert Benjamin L, Levine Ross L
Abstract excerpt
Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of MPN patients and CALR mutations in JAK2-negative MPN patients. However, the role of JAK-STAT pathway activation in different MPNs, and in patients without JAK2 mutations, has not been definitively delineated. We used expression profiling, single nucleotide...
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