Article
Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.
Clinical and translational science - 1 May 2022
Feldman Keith, Kearns Gregory L, Pearce Robin E, Abdel-Rahman Susan M, Steven Leeder James, Friesen Alec, Staggs Vincent S, Gaedigk Andrea, Weigel Jaylene, Shakhnovich Valentina
Abstract excerpt
The 13 C-pantoprazole breath test (PAN-BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN-BT performance in children, with a focus on discriminating individuals who, according to guidelines from the Clinical Pharmacology Implementation Consortium (CPIC), would benefit from starting dose escalation versus reduction for proton pump inhibitors (PPIs). Children...
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