Article
Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Apr 2009
Miwa Kenji, Inazu Akihiro, Kawashiri Masaaki, Nohara Atsushi, Higashikata Toshinori, Kobayashi Junji, Koizumi Junji, Nakajima Katsuyuki, Nakano Takamitsu, Niimi Manabu, Mabuchi Hiroshi, Yamagishi Masakazu
Abstract excerpt
BACKGROUND: The role of CETP in the development of atherosclerosis is debatable, and few data exist regarding the total impact of CETP inhibition on cholesterol efflux. METHODS: Acceptor capacities of whole serum and HDL subfractions separated by HPLC were compared using 2 different cell systems. Subjects with CETP deficiency (2 homozygous, 1 compound heterozygous, and 5 heterozygous) were analyzed along with 10...
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