Article

ApoA-I dissociated from human HDL retains its acceptor properties in ABCA1-mediated cholesterol efflux from RAW 264.7 macrophages in coronary artery disease

2025-11-21

Abstract excerpt

<h4>ABSTRACT</h4> The significance of cholesterol efflux as a predictor of coronary artery disease (CAD) remains controversial. The major pathway of the export of intracellular cholesterol by the ABCA1 transporter includes the acceptance of effluxed cholesterol by lipid-free apolipoprotein A-I and/or high-density lipoproteins (HDL). To separate the contribution of lipid-free and lipid-bound apoA-I with different...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a57d0cbe-6108-5ef8-b2e9-8a4701dffcea
DOI: 10.1101/2025.11.21.689699

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ApoA-I dissociated from human HDL retains its acceptor properties in ABCA1-mediated cholesterol efflux from RAW 264.7 macrophages in coronary artery diseaseDOI 10.1101/2025.11.21.689699Read

Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.Semantic proximity Read

Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia.Semantic proximity Read

Bioinformatic Analysis of Plasma Apolipoproteins A-I and A-II Revealed Unique Features of A-I/A-II HDL Particles in Human Plasma.Semantic proximity Read

Carboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cells.Semantic proximity Read

Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients.Semantic proximity Read

The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.Semantic proximity Read

Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.Semantic proximity Read

High density lipoproteins and reverse cholesterol transport: lessons from mutations.Semantic proximity Read

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.Semantic proximity Read

Identification of a novel human cellular HDL biosynthesis defect.Semantic proximity Read

Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux.Semantic proximity Read

Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins.Semantic proximity Read