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Article

Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C.

Thrombosis and haemostasis - 1 Jan 2009

Yegneswaran Subramanian, Nguyen Phuong M, Gale Andrew J, Griffin John H

Abstract excerpt

The hypothesis that prothrombin (FII) protects coagulation factor Va (FVa) from proteolytic inactivation by activated protein C (APC) was tested using purified proteins. FII dose-dependently protected FVa from APC proteolysis under conditions where competition of proteins for binding to negatively-charged phospholipid surface was not relevant (i.e. either at high phospholipid vesicle concentrations or using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19132189
DOI: 10.1160/th08-07-0491
PMCID: PMC2730196

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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