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Article

The interaction of prothrombin with phospholipid membranes is independent of either kringle domain.

The Journal of biological chemistry - 25 Jul 1993

Kotkow K J, Furie B, Furie B C

Abstract excerpt

Prothrombin contains two kringle domains, a structural motif common to other plasma proteins involved in hemostasis and fibrinolysis. To determine the role of the kringle domains of prothrombin, we prepared three recombinant human prothrombin forms lacking the first kringle domain (residues 63-144; PT/delta K1), the second kringle domain (residues 144-249; PT/delta K2), or both kringle domains (63-249; PT/delta...

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PMID: 8393451

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