Article
Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity.
Blood - 3 Feb 2011
Wood Jeremy P, Silveira Jay R, Maille Nicole M, Haynes Laura M, Tracy Paula B
Abstract excerpt
Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca(2+)-dependent complex of factors Va and Xa assembled on the activated platelet surface, which cleaves prothrombin at Arg271 and Arg320. Whereas initial cleavage at Arg271 generates the inactive intermediate prethrombin-2, initial cleavage at Arg320 generates the enzymatically active intermediate meizothrombin. To determine...
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