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Article

Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.

The Journal of biological chemistry - 31 Oct 2008

Kamath Parvathi, Krishnaswamy Sriram

Abstract excerpt

Membrane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase. Thrombin is produced in two cleavage reactions. One at Arg(320) yields the proteinase meizothrombin that retains membrane binding properties...

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Identifiers

PMID: 18765660
DOI: 10.1074/jbc.M806158200
PMCID: PMC2573076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18765660-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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