Article
Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.
The Journal of investigative dermatology - 1 Jun 2009
Purdie Karin J, Harwood Catherine A, Gulati Abha, Chaplin Tracy, Lambert Sally R, Cerio Rino, Kelly Gavin P, Cazier Jean-Baptiste, Young Bryan D, Leigh Irene M, Proby Charlotte M
Abstract excerpt
Cutaneous squamous cell carcinomas (cSCCs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cSCC tumorigenesis remain poorly defined. We have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 cSCCs using paired non-tumor samples. The most frequent recurrent aberrations...
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