Article
Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event.
Cancer research - 1 Oct 2005
Teh Muy-Teck, Blaydon Diana, Chaplin Tracy, Foot Nicola J, Skoulakis Spyros, Raghavan Manoj, Harwood Catherine A, Proby Charlotte M, Philpott Michael P, Young Bryan D, Kelsell David P
Abstract excerpt
Basal cell carcinoma is the most common human cancer with increasing incidence reported worldwide. Despite the aberrant signaling role of the Hedgehog pathway, little is known about the genetic mechanisms underlying basal cell carcinomas. Towards a better understanding of global genetic events, we have employed the Affymetrix Mapping 10K single nucleotide polymorphism (SNP) microarray technique for...
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