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Article

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

American journal of physiology. Cell physiology - 1 Mar 2009

Leuthold Simone, Hagenbuch Bruno, Mohebbi Nilufar, Wagner Carsten A, Meier Peter J, Stieger Bruno

Abstract excerpt

Organic anion transporting polypeptides (humans OATPs, rodents Oatps) are expressed in most mammalian tissues and mediate cellular uptake of a wide variety of amphipathic organic compounds such as bile salts, steroid conjugates, oligopeptides, and a large list of drugs, probably by acting as anion exchangers. In the present study we aimed to investigate the role of the extracellular pH on the transport activity...

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PMID: 19129463
DOI: 10.1152/ajpcell.00436.2008

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