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Role of Extracellular Histidine Residues for the Function and pH Sensitivity of Human Organic Anion Transporting Polypeptide 1B3.

Proteins - 1 Oct 2025

Han Wanjun, Liu Han, Liang Ting, Li Lanjing, Huan Ru, Gui Chunshan

Abstract excerpt

Organic anion transporting polypeptide 1B3 (OATP1B3) is a liver-specific transporter that mediates uptake of various substances from blood into hepatocytes. The transport function of OATP1B3 was shown to be pH-sensitive. As the protonation state of extracellular histidine residues can be affected by the environmental pH, in the present study, the role of 7 extracellular histidine residues in the function and pH...

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Bicarbonates
Biological Transport
HEK293 Cells
Histidine
Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrogen-Ion Concentration

Recombinant Proteins

Solute Carrier Organic Anion Transporter Family Member 1B3

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PMID: 40468755
DOI: 10.1002/prot.26851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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