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Article

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.

BMC evolutionary biology - 7 Jan 2009

Hughes David A, Jastroch Martin, Stoneking Mark, Klingenspor Martin

Abstract excerpt

BACKGROUND: Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential for non-shivering thermogenesis (NST) in mammalian BAT. UCP1 orthologs have been identified in non-Eutherian mammals, fish and amphibians. Yet, UCP1...

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Source

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Identifiers

PMID: 19128480
DOI: 10.1186/1471-2148-9-4
PMCID: PMC2627829

Genes

UCP1
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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