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Article

Common mitochondrial DNA mutations generated through DNA-mediated charge transport.

Biochemistry - 3 Feb 2009

Merino Edward J, Davis Molly L, Barton Jacqueline K

Abstract excerpt

Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)(2)bpy]Cl(3) (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to allow the complex to enter the cell and bind mitochondrial DNA. Photoexcitation of DNA-bound [Rh(phi)(2)bpy](3+) can promote the oxidation of guanine from a...

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Identifiers

PMID: 19128037
DOI: 10.1021/bi801570j
PMCID: PMC2668510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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