Article
The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Science (New York, N.Y.) - 24 Feb 2017
O'Brien Elizabeth, Holt Marilyn E, Thompson Matthew K, Salay Lauren E, Ehlinger Aaron C, Chazin Walter J, Barton Jacqueline K
Abstract excerpt
DNA charge transport chemistry offers a means of long-range, rapid redox signaling. We demonstrate that the [4Fe4S] cluster in human DNA primase can make use of this chemistry to coordinate the first steps of DNA synthesis. Using DNA electrochemistry, we found that a change in oxidation state of the [4Fe4S] cluster acts as a switch for DNA binding. Single-atom mutations that inhibit this charge transfer hinder...
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