Article
Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations.
European journal of human genetics : EJHG - 1 Jun 2009
Pardo Luba, Bochdanovits Zoltán, de Geus Eco, Hottenga Jouke J, Sullivan Patrick, Posthuma Danielle, Penninx Brenda W J H, Boomsma Dorret, Heutink Peter
Abstract excerpt
The HapMap project has facilitated the selection of tagging single nucleotide polymorphisms (tagSNPs) for genome-wide association studies (GWAS) under the assumption that linkage disequilibrium (LD) in the HapMap populations is similar to the populations under investigation. Earlier reports support this assumption, although in most of these studies only a few loci were evaluated. We compared pair-wise LD and LD...
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