Article
Population structure, migration, and diversifying selection in the Netherlands.
European journal of human genetics : EJHG - 1 Nov 2013
Abdellaoui Abdel, Hottenga Jouke-Jan, de Knijff Peter, Nivard Michel G, Xiao Xiangjun, Scheet Paul, Brooks Andrew, Ehli Erik A, Hu Yueshan, Davies Gareth E, Hudziak James J, Sullivan Patrick F, van Beijsterveldt Toos, Willemsen Gonneke, de Geus Eco J, Penninx Brenda W J H, Boomsma Dorret I
Abstract excerpt
Genetic variation in a population can be summarized through principal component analysis (PCA) on genome-wide data. PCs derived from such analyses are valuable for genetic association studies, where they can correct for population stratification. We investigated how to capture the genetic population structure in a well-characterized sample from the Netherlands and in a worldwide data set and examined whether (1)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.