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Article

Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression.

Carcinogenesis - 1 Mar 2009

Nikolova Viktoriya, Koo Chuay-Yeng, Ibrahim Sherif Abdelaziz, Wang Zihua, Spillmann Dorothe, Dreier Rita, Kelsch Reinhard, Fischgräbe Jeanett, Smollich Martin, Rossi Laura H, Sibrowski Walter, Wülfing Pia, Kiesel Ludwig, Yip George W, Götte Martin

Abstract excerpt

The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion, migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a membrane-bound coreceptor into a soluble effector capable of binding the same ligands. In breast carcinomas, Sdc1 overexpression correlates with poor prognosis and an aggressive phenotype. To distinguish between the roles of membrane-bound and...

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Identifiers

PMID: 19126645
DOI: 10.1093/carcin/bgp001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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