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The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance

18 Jan 2022

Abstract excerpt

Metastasis and relapse are major causes of cancer-related fatalities. The elucidation of relevant pathomechanisms and adoption of appropriate countermeasures are thus crucial for the development of clinical strategies that inhibit malignancy progression as well as metastasis. An integral component of the extracellular matrix, the type 1 transmembrane glycoprotein syndecan-1 (SDC-1) binds cytokines and growth...

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PMID: 35118073
DOI: 10.3389/fcell.2021.784983

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