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Article

Role of syndecan-4 in breast cancer pathophysiology

12 Sept 2022

Abstract excerpt

Expression of the cell surface heparan sulfate proteoglycan syndecan-4 is dysregulated in breast cancer, the most frequent malignancy in women. High expression of syndecan-4 correlates with a worse survival in the subgroup of estrogen receptor negative and estrogen/progesterone-receptor negative patients. Aberrant expression of syndecan-4 in breast cancer involves both transcriptional and posttranscriptional...

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PMID: 36094435
DOI: 10.1152/ajpcell.00152.2022

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