Article
Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.
Parasitology - 1 Jan 2009
Lantos P M, Ahouidi A D, Bei A K, Jennings C V, Sarr O, Ndir O, Wirth D F, Mboup S, Duraisingh M T
Abstract excerpt
Plasmodium falciparum parasites use multiple ligand-receptor interactions to invade human erythrocytes. Variant expression levels of members of the PfRh and PfEBA ligand families are associated with the use of different erythrocyte receptors, defining invasion pathways. Here we analyse a major polymorphism, a large sequence deletion in the PfRh2b ligand, and erythrocyte invasion profiles in uncultured Senegalese...
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