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Article

Plasmodium falciparum field isolates from South America use an atypical red blood cell invasion pathway associated with invasion ligand polymorphisms.

PloS one - 1 Jan 2012

Lopez-Perez Mary, Villasis Elizabeth, Machado Ricardo L D, Póvoa Marinete M, Vinetz Joseph M, Blair Silvia, Gamboa Dionicia, Lustigman Sara

Abstract excerpt

Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC) invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL) and the Reticulocyte Binding-Like (PfRh) proteins, which are polymorphic and not fully characterized in field isolates. To determine the various P. falciparum invasion pathways used by parasite isolates...

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Identifiers

PMID: 23118907
DOI: 10.1371/journal.pone.0047913
PMCID: PMC3485327

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